Produção Científica

Publicações

Artigos em revistas internacionais produzidos pelos coordenadores do Laboratório de Fitoquímica e Farmacognosia — Prof. Dr. Daniel Demarque e Prof. Dr. Gabriel R. Martins.

2026
2026

Valorization of Hop (Humulus lupulus L.) Brewing Residue as a Natural Photoprotective Adjuvant

Lima AGUB, Pinto CASO, Cândido TM, Pessoa FVLS, Velasco MVR, Demarque DP, Baby AR.

Photochem, v. 6, p. 8, 2026.

FotoproteçãoLúpuloCosméticos
DOI: 10.3390/photochem6010008
2025
2025

Nutraceutical Blends Promote Weight Loss, Inflammation Reduction, and Better Sleep: The Role of in Overweight Adults — A Double-Blind Trial

Santamarina AB, Nehmi Filho V, De Freitas JA, Franco LAM, Martins RC, Fonseca JV, Orellana Turri JA, Hufnagel MT, Demarque DP, Da Silva BFRB, Gusmão AF, Olivieri EHR, De Souza E, De Souza EA, Otoch JP, Pessoa AFM.

Molecular Nutrition & Food Research, v. 1, p. 1, 2025. 4 citações

NutraceuticalsInflamaçãoSono
DOI: 10.1002/mnfr.70030
2025

Development of a semi-preparative LC method for the purification of synthetic cannabinoids impregnated in herbal products for chemical characterization by NMR and HRMS

De Araújo KRG, De Paula Meirelles G, Demarque DP, Dorr F, Júnior LFN, Soares AL, Guedes CD, Da Costa JL, Yonamine M.

Forensic Chemistry, v. 45, p. 100678, 2025. 1 citação

Canabinoides SintéticosRMNHRMSForense
DOI: 10.1016/j.forc.2024.100678
2025

The extraction method determines the chemical profiles of leaves and stems of Melissa officinalis L.

Frazão VP, Hufnagel MT, Dörr F, Pessoa AFM, Demarque DP.

Journal of Pharmacy & Pharmacognosy Research, v. 13, p. 1537–1546, 2025.

Melissa officinalisExtraçãoFitoquímica
DOI: 10.56499/jppres24.2049_13.6.1537
2025

Effects of Long-Term Nutrient Addition on Leaf Metabolites, Herbivory, and Mycorrhizal Spores Associated With a Savannah Woody Species

Martins A, Demarque DP, Dusi RG, Santos CAC, Espindola LS, Da Cunha Bustamante MM.

Austral Ecology, v. 50, p. 1, 2025.

MetabolômicaCerradoEcologia Química
DOI: 10.1111/aec.70011
2024

New Compounds from Terrestrial Plants: A Perspective View

Oliveira ES, Kohatsu CN, Hufnagel MT, Gennaro VF, Demarque DP.

Compounds, v. 4, p. 415–440, 2024.

Produtos NaturaisPlantas TerrestresRevisão
DOI: 10.3390/compounds4030026
2024
2024

Nutraceutical composition (yeast β-glucan, prebiotics, minerals, and silymarin) predicts improvement of sleep quality and metabolic parameters: A randomized pilot study

Santamarina AB, Nehmi Filho V, Freitas JA, Silva BFRB, Gusmão AF, Olivieri EHR, Souza E, Silva SL, Miranda DA, Demarque DP, Oliveira ES, Otoch JP, Pessoa AFM.

Clinical Nutrition ESPEN, v. 63, p. 476–490, 2024. 3 citações

NutraceuticalsSonoβ-Glucana
DOI: 10.1016/j.clnesp.2024.07.1044
2023
2023

Phytocompounds Recovered from the Waste of Cabernet Sauvignon (Vitis vinifera L.) Vinification: Cytotoxicity and In Vitro Photoprotection Efficacy in a Sunscreen System

Hübner AA, Demarque DP, Lourenço FR, Rosado C, Baby AR, Kikuchi IS, Bacchi EM.

Cosmetics, v. 10, p. 2, 2023. 12 citações

FotoproteçãoVitis viniferaFitoquímica
DOI: 10.3390/cosmetics10010002
2023

Edible Plant Extracts against Aedes aegypti and Validation of a Piper nigrum L. Ethanolic Extract as a Natural Insecticide

Morais LS, Sousa JPB, Aguiar CM, Gomes CM, Demarque DP, Albernaz LC, Espindola LS.

Molecules, v. 28, p. 1264, 2023. 6 citações

Aedes aegyptiPiper nigrumInseticida Natural
DOI: 10.3390/molecules28031264
2023

Technological Aspects and Potential Cutaneous Application of Wine Industry By-Products

Hübner AA, De Aguiar MMGB, Demarque DP, Rosado C, Velasco MVR, Kikuchi IS, Baby AR, Pessoa FVLS.

Applied Sciences-Basel, v. 13, p. 9068, 2023. 7 citações

VinhoPeleBy-products
DOI: 10.3390/app13169068
2022
2022

A synergistic Rh(I)/organoboron-catalysed site-selective carbohydrate functionalization that involves multiple stereocontrol

Rao VUB, Wang C, Demarque DP, Grassin C, Otte F, Merten C, Strohmann C, Loh CCJ.

Nature Chemistry, v. 14, p. 1, 2022. 33 citações

Nature ChemistryQ1CarboidratosCatálise
DOI: 10.1038/s41557-022-00992-3
2022

Combining chemometric and phytochemical tools to isolate and characterize activity of compounds against Aedes aegypti

Magalhaes NMG, Sousa JPB, Demarque DP, Salvador CEM, Albernaz LC, Achee NL, Grieco JP, Espindola LS.

Natural Product Research, v. 36, p. 2620–2624, 2022. 5 citações

QuimiometriaAedes aegyptiLarvicida
DOI: 10.1080/14786419.2020.1839473
2021
2021

VCD spectroscopy reveals that a water molecule determines the conformation of azithromycin in solution

Demarque DP, Kemper M, Merten C.

Chemical Communications, v. 57, p. 4031–4034, 2021. 23 citações

VCDAzitromicinaConf. Absoluta
DOI: 10.1039/D1CC00451D
2021

Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors

Demarque DP, Espindola LS.

Frontiers in Chemistry, v. 9, p. 1, 2021. 17 citações

ArboviroseProdutos NaturaisVetores
DOI: 10.3389/fchem.2021.628920
2021

A Molecular Networking Strategy: High-Throughput Screening and Chemical Analysis of Brazilian Cerrado Plant Extracts against Cancer Cells

Cortelo PC, Demarque DP, Dusi RG, Albernaz LC, Braz-Filho R, Goncharova EI, Bokesch HR, Gustafson KR, Beutler JA, Espindola LS.

Cells, v. 10, p. 691, 2021. 15 citações

Redes MolecularesCerradoAnticâncer
DOI: 10.3390/cells10030691
2021

The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control

Valli M, Atanázio LCV, Monteiro GC, Coelho RR, Demarque DP, Andricopulo AD, Espindola LS, Bolzani VS.

Planta Medica, v. 87, p. 6–23, 2021. 9 citações

Plantas MedicinaisControle de Vetores
DOI: 10.1055/a-1232-9771
2021

Cucurbitane Triterpene Glycosides from the Roots of Wilbrandia hibiscoides

Fiori GML, Demarque DP, Pereira AMS, Klein VLG, Lopes NP.

Brazilian Journal of Pharmacognosy, v. 01, p. 1, 2021. 1 citação

TriterpenosGlicosídeosCucurbitaceae
DOI: 10.1007/s43450-021-00151-6
2020
2020

Sensitivity of VCD spectroscopy for small structural and stereochemical changes of macrolide antibiotics

Demarque DP, Heinrich S, Schulz F, Merten C.

Chemical Communications, v. 56, p. 10926–10929, 2020. 18 citações

VCDMacrolídeosEstereoquímica
DOI: 10.1039/D0CC04082H
2020

Mass spectrometry-based metabolomics approach in the isolation of bioactive natural products

Demarque DP, Dusi RG, De Sousa FDM, Grossi SM, Silvério MRS, Lopes NP, Espindola LS.

Scientific Reports, v. 10, p. 1051, 2020. 80 citações

MetabolômicaScientific ReportsQ1
DOI: 10.1038/s41598-020-57987-0
2020

Antileishmanial compounds from Connarus suberosus: Metabolomics, isolation and mechanism of action

Morais LS, Dusi RG, Demarque DP, Silva RL, Albernaz LC, Bão SN, Merten C, Antinarelli LMR, Coimbra ES, Espindola LS.

PLoS One, v. 15, p. e0241855, 2020. 16 citações

LeishmanioseMetabolômicaMecanismo de Ação
DOI: 10.1371/journal.pone.0241855
2020

Residual Larvicidal Activity of Quinones against Aedes aegypti

Silva RL, Demarque DP, Dusi RG, Sousa JPB, Albernaz LC, Espindola LS.

Molecules, v. 25, p. 3978, 2020. 33 citações

QuinonasLarvicidaAedes aegypti
DOI: 10.3390/molecules25173978
2020

Involvement of Isoorientin in the Antidepressant Bioactivity of a Flavonoid-Rich Extract from Passiflora edulis f. flavicarpa Leaves

Alves JSF, Marques JI, Demarque DP, Costa LRF, Amaral JG, Lopes NP, Da Silva-Júnior AA, Soares LAL, Gavioli EC, Ferreira LS, Zucolotto SM.

Brazilian Journal of Pharmacognosy, v. 30, p. 240–250, 2020. 12 citações

PassifloraFlavonoidesAntidepressivo
DOI: 10.1007/s43450-020-00023-3
2020

Dereplication and Isolation of Larvicidal Compounds From Annonaceae Species Against Aedes aegypti

De Sousa FDM, Grossi SM, Monteiro GC, Demarque DP, Espindola LS.

Brazilian Journal of Pharmacognosy, v. 30, p. 123–126, 2020. 5 citações

DesreplicaçãoAnnonaceaeLarvicida
DOI: 10.1007/s43450-020-00027-z
2020

Synthesis, phytotoxic evaluation and in silico studies for the development of novel natural products-inspired herbicides

Rodrigues RP, Baroni ACM, Carollo CA, Demarque DP, Pardo LFL, De Rezende LMP, Dos Santos FJL, Lima WG, De Siqueira JM.

Biocatalysis and Agricultural Biotechnology, v. 24, p. 101559, 2020. 4 citações

HerbicidasFitotoxicidadeIn Silico
DOI: 10.1016/j.bcab.2020.101559
2019

Pharmacokinetic disposition of erythraline in rats after intravenous administration

Demarque DP, Callejon DR, Pinto LG, Gouvea DR, De Moraes NV, Lopes JLC, Lopes JNC, Lopes NP, Guaratini T.

Revista Brasileira de Farmacognosia, v. 29, p. 773–777, 2019. 2 citações

FarmacocinéticaEritralinaAlcaloides
DOI: 10.1016/j.bjp.2019.07.004
2018
2018

Revisiting empirical rules for the determination of the absolute configuration of cascarosides and other (ox-)anthrones

Demarque DP, Pinho DR, Lopes NP, Merten C.

Chirality, v. 1, p. 1–7, 2018. 9 citações

Configuração AbsolutaAntraquinonasCascarosídeos
DOI: 10.1002/chir.22890
2018

Cytotoxic Triterpenes from Salacia crassifolia and Metabolite Profiling of Celastraceae Species

Espindola L, Dusi R, Demarque D, Braz-Filho R, Yan P, Bokesch H, Gustafson K, Beutler J.

Molecules, v. 23, p. 1494, 2018. 20 citações

TriterpenosCelastraceaeCitotoxicidade
DOI: 10.3390/molecules23061494
2018

Cytotoxicity of Structurally Diverse Anthranoids and Correlation with Mechanism of Action and Side Effects

Demarque DP, Silva RMP, Santos LF, Leopoldino AM, Espreafico EM, Lopes NP.

Journal of Pharmacy and Pharmaceutical Sciences, v. 21, p. 347, 2018. 1 citação

AntranoidesCitotoxicidadeMecanismo de Ação
DOI: 10.18433/jpps29919
2018

Isolation and Identification of Five Novel Flavonoids from Genipa americana Leaves

Silva L, Alves J, Da Silva Siqueira E, De Souza Neto M, Abreu L, Tavares J, Porto D, De Santis Ferreira L, Demarque D, Lopes N, Aragão C, Zucolotto S.

Molecules, v. 23, p. 2521, 2018. 21 citações

FlavonoidesGenipa americanaCompostos Novos
DOI: 10.3390/molecules23102521
2018

The role of tannins as antiulcer agents: a fluorescence-imaging based study

Demarque DP, Callejon DR, De Oliveira GG, Silva DB, Carollo CA, Lopes NP.

Revista Brasileira de Farmacognosia, v. 28, p. 425–432, 2018. 18 citações

TaninosAntiúlceraFluorescência
DOI: 10.1016/j.bjp.2018.04.009
2018

New cascarosides from Rhamnus purshiana and fragmentation studies of the class by IT-MS

Demarque DP, Pinho DR, Callejon DR, De Oliveira GG, Silva DB, Carollo CA, Lopes NP.

Rapid Communications in Mass Spectrometry, v. 31, p. 1169, 2018. 11 citações

CascarosídeosFragmentação MSRhamnus
DOI: 10.1002/rcm.7893
2017
2017

Achyrocline alata potentiates repair of skin full thickness excision in mice

Pereira LX, Silva HKC, Longatti TR, Silva PP, Di Lorenzo Oliveira C, De Freitas Carneiro Proietti AB, Thomé RG, Vieira MC, Carollo CA, Demarque DP, De Siqueira JM, Dos Santos HB, Parreira GG, De Azambuja Ribeiro RIM.

Journal of Tissue Viability, v. 26, p. 289–299, 2017. 12 citações

AchyroclineCicatrizaçãoPele
DOI: 10.1016/j.jtv.2017.07.003
2017

Intra- vs. intermolecular hydrogen bonding: Solvent-dependent conformational preferences of a common supramolecular binding motif from ¹H-NMR and VCD spectra

Demarque DP, Merten C.

Chemistry – A European Journal, v. 23, p. 1–9, 2017. 29 citações

VCDLigação de HidrogênioConformação
DOI: 10.1002/chem.201702705
2016
2016

Fragmentation reactions using electrospray ionization mass spectrometry: an important tool for the structural elucidation and characterization of synthetic and natural products

Demarque DP, Crotti AEM, Vessecchi R, Lopes JLC, Lopes NP.

Natural Product Reports, v. 33, p. 432–455, 2016. 415 citações

ESI-MSFragmentaçãoNatural Product ReportsQ1
DOI: 10.1039/C5NP00073D
2016

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking (GNPS)

Wang M, Carver JJ, Phelan VV, Sanchez LM, …, Demarque DP, et al.

Nature Biotechnology, v. 34, p. 828–837, 2016. 3.470 citações

Nature BiotechnologyGNPSQ13470 citações
DOI: 10.1038/nbt.3597
2016

Dereplication of Flavonoid Glycoconjugates from Adenocalymma imperatoris-maximilianii by Untargeted Tandem Mass Spectrometry-Based Molecular Networking

De Oliveira G, Carnevale Neto F, Demarque D, De Sousa Pereira-Junior JS, Sampaio Peixoto Filho R, De Melo S, Da Silva Almeida J, Lopes J, Lopes N.

Planta Medica, v. 83, p. 636, 2016. 36 citações

Redes MolecularesFlavonoidesDesreplicação
DOI: 10.1055/s-0037-1608133
2015
2015

Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis

Peres RS, Liew FY, Talbot J, Carregaro V, Oliveira RD, Almeida SL, França RFO, Donate PB, Pinto LG, Ferreira FIS, Costa DL, Demarque DP, Gouvea DR, Lopes NP, Queiroz RHC, Silva JS, Figueiredo F, Alves-Filho JC, Cunha TM, Ferreira SH, et al.

PNAS, v. 112, p. 2015. 114 citações

PNASArtrite ReumatoideCD39Metotrexato
DOI: 10.1073/pnas.1424792112
2015

Optimization and Technological Development Strategies of an Antimicrobial Extract from Achyrocline alata Assisted by Statistical Design

Demarque DP, Fitts SMF, Boaretto AG, Da Silva JCL, Vieira MC, Franco VNP, Teixeira CB, Toffoli-Kadri MC, Carollo CA.

PLoS One, v. 10, p. e0118574, 2015. 8 citações

AchyroclineAntimicrobianoDelineamento Estatístico
DOI: 10.1371/journal.pone.0118574
2015

In vitro anti-Leishmania infantum activity of essential oil from Piper angustifolium

Bosquiroli LSS, Demarque DP, Rizk YS, Cunha MC, Marques MCS, Matos MFC, Kadri MCT, Carollo CA, Arruda CCP.

Revista Brasileira de Farmacognosia, v. 25, p. 124–128, 2015. 31 citações

LeishmaniaPiperÓleo Essencial
DOI: 10.1016/j.bjp.2015.01.006
2014
2014

Physicochemical, microbiological and sensory evaluation of a bioactive food blend

Ferreira RS, Hiane PA, Guimarães RCA, Ramos MIL, Demarque DP, Meira JEC.

Ciência e Tecnologia de Alimentos, v. 34, p. 609–615, 2014. 1 citação

Alimentos FuncionaisBioativo
DOI: 10.1590/1678-457X.6374
2012
2012

Allelopathic activity of Matricaria chamomilla essential oil by the bioautography test

Demarque DP, Saboia JF, Fabri JR, Carollo CA.

Allelopathy Journal, v. 29, p. 171–176, 2012. 7 citações

AlelopatiaCamomilaÓleo Essencial
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Demarque DP: >30 artigos, >2.300 citações (excluindo GNPS). Para lista completa acesse os perfis acadêmicos.

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